Assaf Zinger

The Zinger Lab aims to create advanced bioinspired technologies and translational therapeutics through a highly multidisciplinary approach. Specifically, we integrate in vitro and in vivo models with imaging, molecular biology, and chemical techniques to design novel nano-based technologies that will achieve organ and cell-specific targeting for improved therapeutic outcomes in different brain and neural diseases and injuries and various cancers.

Website:    http://www.thezingerlab.com/

Tweeter:   @ZingerAssaf

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Zinger, A.; Sushnitha, M.; Naoi, T.; Baudo, G.; Chang, J.; De Rosa, E.; Tasciotti, E.; Taraballi, F. Enhancing Inflammation Targeting Using Tunable Leukocyte-based Biomimetic Nanoparticles. ACS nano 2021, https://doi.org/10.1021/acsnano.0c05792. Co-corresponding, Equal first, Supplementary cover, (IF=14.58).

Zinger, A.; Soriano, S.; Baudo, G.; De Rosa, E.; Taraballi, F.; Villapol, S.; Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury. Advanced Functional Materials 2021, https://doi.org/10.1002/adfm.202100722. Co-corresponding, (IF=16.8).

Zinger, A.; Baudo, G.; Naoi, T.; Giordano, F.; Lenna, S.; Massaro, M.; Ewing, A.; Kim, H.R.; Tasciotti, E.; Yustein, J.; Taraballi, F. Reproducible and Characterized Method for Ponatinib Encapsulation into Biomimetic Lipid Nanoparticles as a Platform for Multi Tyrosine Kinase Targeted Therapy. ACS Applied Bio Materials 2020. https://doi.org/10.1021/acsabm.0c00685Cocorresponding, Supplementary cover, (IF= under consideration).

Zinger, A.; Koren, L.; Adir, O.; Poley, M.; Alyan, M.; Yaari, Z.; Noor, N.; Krinsky, N.; Simon, A.; Gibori, H.; Krayem, M.; Mumblat, Y.; Kasten, S.; Ofir, S.; Fridman, E.; Milman, N.; Lübtow, M.M.; Liba, L.; Shklover, J.; Shainsky-Roitman, J.; Binenbaum, Y.; Hershkovitz, D.; Gil, Z.; Dvir, T.; Luxenhofer, R.; Satchi-Fainaro, R.; Schroeder, A. Collagenase nanoparticles enhance the penetration of drugs into pancreatic tumors. ACS nano 2019, 13, 11008-11021. https://doi.org/10.1021/acsnano.9b02395, Supplementary cover, (IF=13.9).

Zinger, A.; Adir, O.; Alper, M.; Simon, A.; Poley, M.; Tzror, C.; Yaari, Z.; Krayem, M.; Kasten, S.; Nawy, G.; Herman, A.; Nir, Y.; Akrish, S.; Klein, T.; Shainsky-Roitman, J.; Hershkovitz, D.; Schroeder, A. Proteolytic Nanoparticles Replace a Surgical Blade by Controllably Remodeling the Oral Connective Tissue. ACS Nano 2018, 12, 1482-1490, doi:10.1021/acsnano.7b07983. (IF=13.9).

Dror, S.; Sander, L.; Schwartz, H.; Sheinboim, D.; Barzilai, A.; Dishon, Y.; Apcher, S.; Golan, T.; Greenberger, S.; Barshack, I.; Malcov, H.; Zilberberg, A.; Levin, L.; Nessling, M.; Friedmann, Y.; Igras, V.; Barzilay, O.; Vaknine, H.; Brenner, R.; Zinger, A.; Schroeder, A.; Gonen, P.; Khaled, M.; Erez, N.; Hoheisel, J.D.; Levy, C. Melanoma miRNA trafficking controls tumour primary niche formation. Nat Cell Biol 2016, 18, 1006-1017, doi:10.1038/ncb3399. (IF=20.06).

Yaari, Z.; da Silva, D.; Zinger, A.; Goldman, E.; Kajal, A.; Tshuva, R.; Barak, E.; Dahan, N.; Hershkovitz, D.; Goldfeder, M.; Roitman, J.S.; Schroeder, A. Theranostic barcoded nanoparticles for personalized cancer medicine. Nat Commun 2016, 7, 13325, doi:10.1038/ncomms13325. (IF=11.88).

Amit, M.; Takahashi, H.; Dragomir, M.P.; Lindemann, A.; Gleber-Netto, F.O.; Pickering, C.R.; Anfossi, S.; Osman, A.A.; Cai, Y.; Wang, R.; Knutsen, E.; Shimizu, M.; Ivan, C.; Rao, X.; Wang, J.; Silverman, D.A.; Tam, S.; Zhao, M.; Caulin, C.; Zinger, A.; Tasciotti, E.; Dougherty, P.M.; ElNaggar, A.; Calin, G.A.; Myers, J.N. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 2020, 578, 449-454, doi:10.1038/s41586-020-1996-3. Cover, (IF=43.07).