A group of people sitting together

Yeshayahu Talmon

Professor Emeritus

Research Fields

Complex Liquids and Self-Assembly, Transmission and Scanning Electron Microscopy of Nanostructured Liquid Systems, Cryo-electron Microscopy: Theory and Methodology Development, Applications of Electron Microscopy in Chemical Engineering, Biology, Food Technology and Polymer Science.

Research Topics

Self-assembly in complex liquids The research program has the general theme of studying self-assembly and nanostructure, on the supra-molecular level, in systems of interest in basic science and in technology. Much of the effort has been focused on self-assembly systems and complex liquids, because these fascinating systems play an important role in areas from physics and chemistry to biology and medicine. The approach in this work has been direct imaging of the nanostructures studied, and correlating the images obtained to results of indirect methods, to rule out experimental artifacts, and to obtain precise quantitative data. An important part of the work has been the understanding of nanostructure/system properties relations, and testing and developing theories that describe the thermodynamics of these systems. The major tool in our studies has been the electron microscope. A substantial part of our microscopy is done at cryogenic temperatures as this enables us to directly visualize complex liquids at their native state. We use light-microscopy and image analysis and reconstruction to augment TEM and SEM work. Small-angle x-ray scattering (SAXS) is also applied regularly in the work to obtain quantitative data, based on our electron micrographs. Among the systems we have studied lately are carbon nanotubes in super acids, blood nanovesicles, microemulsions, and the interaction between polyelectrolytes and oppositely charged amphiphiles.


Behabtu, N., Young, C.C., Tsentalovich1, D.E., Kleinerman, O., Wang, X., Ma, A.W.K., Bengio, E.A., ter Waarbeek, R.F., de Jong, J.J., Hoogerwerf, R.E., Fairchild, S.B., Ferguson, J.B., Maruyama, B., Kono, J., Talmon, Y., Cohen, Y., Otto, M.J., and Pasquali, M., Strong, Light, Multi-Functional Fibers of Carbon Nanotubes with Ultrahigh Conductivity, Science 339, 182-186 (2013).

Carboni, M., Falchi, A.M., Lampis, S., Sinico, C., Manca, M.L., Schmidt, J., Talmon, Y., Murgia, S., and Monduzzi, M., Physicochemical, Cytotoxic, and Dermal Release Features of a Novel Cationic Liposome Nanocarrier, Adv. Healthcare Mater., 2, 692–701 (2013)

Shi, H., Ge, W., Oh, H., Pattison, S.M., Huggins, J.T., Talmon, Y., Hart, D.J., Raghavan, S.R., and Zakin, J.L., A Photoreversible Micellar Solution as Smart Drag-Reducing Fluid for Use in District Heating/Cooling Systems, Langmuir 29, 102-109 (2013).

Caltagirone, C., Murgia, S., Prodi, L., Bonacchi, S., Lippolis, V., Monduzzi, M., Lampis, S., Talmon, Y., Falchi, A.M., Schmidt, J., and Meli, V., Drug Loaded Fluorescent Cubosomes: Versatile Nanoparticles for Potential Theranostic Applications, Langmuir 29, 6673-6679 (2013).

Aytar, B.S., Muller, J.P.E., Kondo, Y., Talmon, Y., Abbott, N.L., and Lynn, D.M., Redox-Based Control of the Transformation and Activation of siRNA Complexes in Extracellular Environments Using Ferrocenyl Lipids, JACS 135, 9111-9120 (2013).

Koifman, N., Schnabel-Lubovsky, M., and Talmon, Y., Nanostructure Formation in the Lecithin/Isooctane/Water System, J. Phys. Chem. B 117, 9558 – 9567 (2013).

Yaroslavov, A.A., Sybachin, A.V., Zaborova, O.V., Orlov, V.N., Ballauff, M., Talmon Y., and Menger, F.M., Lipid Segregation in Membranes of Anionic Liposomes Adsorbed onto Polycationic Brushes, Chemistry – A European Journal 19, 13674-13678 (2013).

Attili-Qadri, S., Karra, N., Nemirovski, A., Schwob, O., Talmon, Y., Nassar, T., and Benita, S., An Oral Delivery System Prolongs Blood Circulation of Docetaxel Nanocapsules via Lymphatic Absorption, Proc. Natl. Acad. Sci. 110, 17498-17503 (2013).

Bencini, A., Caddeo, F., Caltagirone, C., Garau, A., Hurstouse, M.B., Isaia, F., Lampis, S., Lippolis, V., Lopez, F., Meli, V., Monduzzi, M., Mostallino, C., Murgia, S., Puccioni, S., Schmidt, J., Secci, P.P., and Talmon, Y., An OFF-ON Chemosensor for Biological and Environmental Applications: Sensing Cd2+ in Water by Catanionic Vesicles and in Living Cells, Org. Biomol. Chem. 11, 7751-7759 (2013).

Issman, L., Brenner, B., Talmon, Y., and Aharon, A., Cryogenic Transmission Electron Microscopy Nanostructural Study of Shed Microparticles, PLOS ONE 8, e83680, 1-9 (2013).

Burrows, N., Kesselman, E., Sabyrov, K., Stemig, A., Talmon, Y., and Penn, R.L., “Crystalline Nanoparticle Aggregation in Non-Aqueous Solvents”, Cryst. Eng. Comm. 16, 1472-1481 (2014).

Shi, H., Ge, W., Wang, Y., Fang, B., Huggins, J.T., Russell, T.A., Talmon, Y., Hart, D.J., and Zakin, J.L., A Drag Reducing Surfactant Threadlike Micelle System with Unusual Rheological Responses to pH, J. Colloid Interface Sci. 418, 95-102 (2014).

Sybachin, A.V., Zaborova, O.V., Orlov, V.N., Semenyuk, P.I., Ballauff, M., Kesselman, E., Schmidt,, J., Talmon, Y., Menger, F.M., and Yaroslavov, A.A., Complexes between Anionic Liposomes and Spherical Polycationic Brushes. An Assembly of Assemblies, Langmuir 30, 2441−2447 (2014).

Bengio, E., Tsentalovich, D., Behabtu, N., Kleinerman, O., Kesselman, E., Schmidt, J., Talmon, Y., and Pasquali, M., Statistical Length Measurement Method by Direct Imaging of Carbon Nanotubes, Applied Materials & Interfaces 6, 6139−6146 (2014).

Hoffmann, H., Dieter Gräbner, D., Förster, S., Rosenfeldt, S., Linders, J., Talmon, Y.; Schmidt, J., Hydrogels from phospholipid vesicles, Advances in Colloid and Interface Science 208, 252-263 (2014).

Caltagirone, C., Falchi, A., Lampis, S., Lippolis, V., Meli, V., Monduzzi, M., Prodi, L., Schmidt, J., Sgarzi, M., Talmon, Y., Bizzari, R., and Murgia, S., Cancer Cell-Targeted Theranostic Cubosomes, Langmuir 30, 6228-6236 (2014).

Rose, J.L., Tata, B.V.R., Talmon, Y., Aswal, V.K., Hassan, P.A., Sreejith, L., Micellar solution with pH responsive viscoelasticity and colour switching property, RSC Adv. 5, 11397-11404 (2015).

Rose, J.L., Tata, B.V.R., Aswal, V.K., Hassand, P.A., Talmon, Y. and Sreejith, L., pH-Switchable Structural Evolution in Aqueous Surfactant – Aromatic Dibasic acid System, European Physical Journal E Eur. Phys. J. E 38, 1-9 (2015).

Yaroslavov, A.A., Sybachin, A.V., Zaborova, O.V., Migulin, V.A., Samoshin, V.V., Ballauff, M., Kesselman, E., Schmidt, J., Talmon, Y., and Menger, F.M., Capacious and Programmable Multi-Liposomal Carriers, Nanoscale 7, 1635-1641 (2015).

Karayil, J., Kumar, S., Hassan, P.A., Talmon, Y., and Sreejith, L., “Microstructural Transition of Aqueous CTAB Micelles in Presence of Long Chain Alcohol”, RSC Advances 5, 12434-12441 (2015).

Caltagirone, C., Arca, M., Falchi, A.M, Lippolis, V., Meli, V., Monduzzi, M., Nylander, T., Rosa, A., Schmidt, J., Talmon, Y., and Murgia, S., Solvatochromic Fluorescent BODIPY Derivative as Imaging Agent in Camptothecin Loaded Hexosomes for Possible Theranostic Applications, RSC Adv. 5, 23443-23449 (2015).

Jacoby, G., Cohen, K., Barkan, K., Talmon, Y., Peer, D., and Beck, R., “Metastability in Lipid Based Particles Exhibits Temporally Deterministic and Controllable Behavior”, Scientific Reports (Nature) 5, Article number: 9481 (2015).

Murgia, S., Falchi, A.M., Meli, V., Schillén, K., Lippolis, V., Monduzzi, M., Rosa, A., Schmidt, J., Talmon, Y., Bizzarri, R., Caltagirone, C., Cubosome formulations stabilized by a dansyl-conjugated block copolymer for possible nanomedicine applications, Coll. Surfaces B 129, 87-94 (2015).

Rose J., L., Tata, B.V.R., Talmon, Y., Aswal, V.K., Hassan, P.A., and Sreejith, L., “Distinctive Effect of Maleic Acid and Fumaric Acid on Structural Transitions in Cationic Micellar Solution”, Colloid Polym. Sci. 293, 1383-1390, (2015).

Kleinerman, O., Parra-Vasquez, A.N., Green, M., Behabtu, N., Schmidt, J., Kesselman, E., Young, C., Cohen, Y., Pasquali, M., and Talmon, Y., Cryogenic-Temperature Electron Microscopy Direct Imaging of Carbon Nanotubes and Graphene Solutions in Superacids, J. Microsc. (on-line).

Talmon, Y., Cryo-EM in the Study of Nanostructured Liquids: A Status Report, Ionic Liquids (on line§).