A group of people sitting together

Hossam Haick

Haick
Professor
Phone:
8293087
hhossam@technion.ac.il
Room:
357
Links:

Research Fields

Artificial olfactory systems based on arrays of nanosensors &bull
Screening and diagnosis of disease via volatile biomarkers &bull
Artificial skin &bull Molecule-based electronic devices and sensors &bull
Electrical characteristics of molecularly-modified nanomaterials and devices
The current research of the LNBD team harnesses nanotechnology and medicine to develop and test a tailor-made, non-invasive array of nanosensors for the detection of volatile biomarkers that will indicate an increased risk of disease (e.g., lung cancer, breast cancer, colorectal cancer, prostate cancer, Kidney Disease, Parkinson, Alzheimer, Multiple Sclerosis, etc.) and assist clinicians to decide for the proper therapy algorithm.
To achieve these goals, we develop a tool that is based on Nano Artificial NOSE (NA-NOSE) as well as artificial skin, which makes use of cross-selective and sensitive sensor arrays that are trained in their ensemble to detect disease biomarkers.
These bio-inspired systems are used to screen and identify high risk groups for specific disease, and monitor the therapy provided to people affected by that disease to establish point-of-care diagnostics and less invasive treatments.
Additionally, they are used for lab-track analysis and, in parallel, for clinical-track analyses.
The LNBD research includes seven essential phases of materials developments, device development, system integration, testing of the bio-inspired systems in lab and clinical environments, application of the bio-inspired systems to disease diagnosis, wide spread screening of high-risk population, guiding surgery, success monitoring of therapy to foster personalized and thus least invasive therapy, basic research e.g. gene profiling, categorizing sub-types of disease, understanding causes of the diseases and dissemination as well as exploitation of project results/hardware.
Specific research activities include:
• Development and characterization of nanomaterial-based artificial skin. •
Development and characterization of integrated sensing matrixes. •
Self-administered plasters for the detection of Tuberculosis via skin. •
Understanding the (gaseous) sensing mechanism of molecule-terminated silicon nanowire field effect transistors. •
Development and characterization of nanomaterial-based sensors and nanomedical artificial olfactory systems (so-called, NA-NOSE). •
Diagnosing and monitoring cancer (lung, breast, colon, gastric, ovarian, kidney, bladder, and head&neck cancers) via breath samples. •
Early detection of lung cancer through bronchial epithelial gene changes – towards targeted therapy. • Detection and classification of internal diseases (e.g., Chronic and Acute Kidney Failure, Intentional Bowl Disease (IBD), Crohn’s disease, Pulmonary Hypertension, Toxemia, etc.) via breath samples. •
Detection and classification of neurodegenerative diseases (Parkinson, Alzheimer, and Multiple Sclerosis) via exhaled breath samples. • Sensors based on random network of carbon nanotubes and/or polycyclic aromatic hydrocarbons for sensing applications under real-world humidity conditions.

Publications

Konvalina, G.; Leshansky, A.; Haick, H. Printing Nanostructures with a Propelled Anti-Pinning Ink Droplet. Adv. Funct. Mater. 25, 2411–2419 (2015).

Segev-Bar, M.; Konvalina, G.; Haick, H. High Resolution Unpixelated Electronic Skin Strip with Anti-Parallel Thickness Gradients of Nanoparticles. Adv. Mater. 27(10), 1779-1784 (2015).

Shehada, N.; Brönstrup, G.; Funka, K.; Christiansen, S.; Leja, M.; Haick, H. Ultrasensitive Silicon Nanowire for Real-World Gas Sensing: 2 Noninvasive Diagnosis of Cancer from Breath Volatolome. Nano Lett. 15(2), 1288–1295 (2015)

Amal, H.; Shi, D. –Y.; Ionescu, R.; Zhang, W. Hua, Q. –L.; Pan, Y. –Y.; Tao, L.; Tao, L.; Liu, H.; Haick, H. Assessment of Ovarian Cancer Conditions from Exhaled Breath. Int. J. Cancer 136, E614–E622 (2015).

Nakhleh, M.; Broza, Y. Y. Haick, H. Monolayer-Capped Gold Nanoparticles for Disease Detection from Breath. Nanomedicine (Future Medicine) 9, 1991–2002 (2014).

Davies, M. P. A.; Barash, O.; Jeries, R.; Peled, N.; Ilouze, M.; Hyde, R.; Marcus, M. W.; Field, J. K.; Haick, H. Unique volatolomic signatures of TP53 and KRAS in lung cells. Br. J. Cancer 111, 1213–1221 (2014).

Nakhleh, M. K.; Amal, H.; Awad, H.; Gharra, A.; Abu-Saleh, N.; Jeries, R.; Haick, H.; Abassi, Z. Sensor Arrays Based on Nanoparticles for Early Detection of Kidney Injury by Breath Samples. Nanomedicine (New York, NY, US) 10, 1767–1776 (2014).

Nakhleh, M. K.; Jeries, R.; Gharra, A.; Binder, A.; Broza, Y. Y.; Pascoe, M.; Dheda, K.; Haick, H. Detecting Active Pulmonary Tuberculosis with a Breath Test Using Nanomaterial-Based Sensors. Europ. Resp. J. 43, 1522 – 1525 (2014).

Broza, Y. Y.; Zuri, L.; Haick, H. Combined Volatolomics for Monitoring of Human Body Chemistry. Nature Sci. Rep. 4: (2014) (doi: 10.1038/srep04611)

Wang, B.; Cancilla, J. C.; Torrecilla, J.; Haick, H. Artificial Sensing Intelligence with Silicon Nanowires for Ultra-Selective Detection in the Gas Phase. Nano Lett. 14, 933-938 (2014).

Haick, H.*; Broza, Y. Y.; Mochalski, P.; Ruzsanyi, V.; Amann, A. Assessment, Origin, and Implementation of Breath Volatile Cancer Markers. Chem. Soc. Rev. 43, 1423-1449 (2014).

Konvalina, G; Haick, H. Sensors for Breath Testing: From Nanomaterials to Comprehensive Disease Detection. Acc. Chem. Res. 47, 66–76 (2014).

Segev-Bar, M.; Haick, H. Flexible Sensors Based on Nanoparticles. ACS Nano 7, 8366–8378 (2013).

Cohen-Kaminsky, S.; Nakhleh, M.; Perros, F.; Montani, D.; Girerd, B.; Garcia, G.; Simonneau, G.; Haick, H.; Humbert, M. A Proof of Concept for the Detection and Classification of Pulmonary Arterial Hypertension through Breath Analysis with a Sensor-Array. Am. J. Resp. Crit. Care Med. 188, 156-759 (2013).

Peled, N.; Barash, O.; Tisch, U.; Ionescu, R.; Ilouze, M.; Mattei, M.; Bunn, P. A. Jr R., Hirsch, F. R.; Haick, H. Volatile Fingerprints of Cancer Specific Genetic Mutations. Nanomedicine (New York, NY, US) 9(6), 758-766 (2013).

Broza, Y.; Haick, H. Nanomaterial-based Sensors for Detection of Disease by Volatile Organic Compounds. Nanomedicine (London, UK) 8, 785-806 (2013) – An Invited Review.

Xu, Z. –Q.; Ionsecu, R.; Broza, Y.; Tisch, U.; Ding, L.; Liu, H.; Song, Q.; Pan, Y. –Y.; Xiong, F. -X.; Gu, K. –S.; Sun, G. –P.; Chen, Z. -D.; Leja, M.; Haick, H. The Breathprints of Gastric Cancer and Benign Gastric Conditions. Br. J. Cancer 108(4), 941-950 (2013).

Hakim, M.; Broza, Y. Y.; Barash, O.; Peled, N.; Phillips, M.; Amann, A.; Haick, H. Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways. Chem. Rev. 112 (11), 5949–5966 (2012).

Peled, N.; Hakim, M.; Tisch, U.; Bunn, P. A. Jr. R.; Miller, Y. E.; Kennedy, T. C.; Mattei, J.; Mitchell, J. D.; Weyant, M. J.; Hirsch, F. R.; Haick, H. Non-invasive Breath Analysis of Pulmonary Nodules. J. Thorac. Oncol. 7(10), 1528-1533 (2012).

Assad, O.; Leshansky, A. M.; Stelzner, T.; Christiansen, S.; Haick, H. A Spray-Coating Route for Highly Aligned and Large-Scale Arrays of Silicon Nanowires. ACS NANO 6(6), 4702-4712 (2012).

Paska, Y.; Stelzner, T.; Tisch, U.; Assad, O.; Christiansen, S.; Haick, H. Molecular Gating of Silicon Nanowire Field Effect Transistors with Nonpolar Analytes. ACS NANO 6(1), 335-345 (2012).

Tisch, U.; Aluf, A.; Ionescu, R.; Nakhle, M.; Bassal, R.; Axelrod, N.; Robertman, D.; Tessler, Y.; Finberg, J. P. M.; Haick, H. Towards a Breath Test for Early Parkinson’s Disease: Carbon Nanotube Sensors for Detecting Asymptomatic Nigro-Striatal Dopaminergic Lesion in Rats. ACS Chem. Neurosci. 3(3), 161-166 (2012).

Barash, O.; Peled, N.; Bunn, P. A. Jr.; Hirsch, F. R.; Haick, H. Classification of lung cancer histology by gold nanoparticle sensors. Nanomedicine (New York, NY, US), 8(5), 580-589 (2012).

Marom, O.; Nakhoul, F.; Tisch, U.; Shiban, A.; Abassi, Z.; Haick, H. A Breath Test for Chronic Kidney Disease and Disease Progression. Nanomedicine (London, UK), 7(5), 639-650 (2012).

Zilberman, Y.; Ionescu, R.; Feng, X.; Müllen, K.; Haick, H. A Nano Array of Polycyclic Aromatic Hydrocarbons and Carbon Nanotubes for Accurate and Predictive Detection in Real-World Environmental Humidity. ACS NANO 5(8), 6743–6753 (2011).

Paska, Y.; Stelzner, T.; Christiansen, S.; Haick, H. Enhanced Sensing of Nonpolar Volatile Organic Compounds by Silicon Nanowire Field Effect Transistors, ACS NANO 5(7), 5620-5626 (2011).

Hakim, M.; Billan, S.; Tisch, U.; Peng, G.; Dvorkind, I.; Marom, O.; Abdah-Bortnyak, R.; Kuten, A.; Haick, H. Diagnosis of Head&Neck Cancer from Exhaled Breath. Br. J. Cancer 104, 1649-1655 (2011).

Peng, G.; Hakim, M.; Broza, Y. Y.; Billan, S.; Abdah-Bortnyak, R.; Kuten, A.; Tisch, U.; Haick, H. Detection of Lung, Breast, Colorectal, and Prostate Cancers from Exhaled Breath using a Single Array of Nanosensors. British J. Cancer 103, 542 – 551 (2010).

Zilberman, Y.; Tisch, U.; Shuster, G.; Pisula, W.; Feng, X.; Müllen, K.; Haick, H. Carbon Nanotube/Hexa-peri-hexabenzocoronene Bilayers for Discrimination between Nonpolar Volatile Organic Compounds of Cancer and Humid Atmospheres. Adv. Mater. 22, 4317–4320 (2010).

Paska, Y.; Haick, H. Systematic Cross-Linking Changes within a Self-Assembled Monolayer in a Nanogap Junction: A Tool for Investigating the Intermolecular Electronic Coupling. J. Am. Chem. Soc. 132(6), 1774-1775 (2010).

Peng, G.; Tisch, U.; Adams, U.; Hakim, M.; Shehada, N.; Broza, Y. Y.; Billan, S.; Abdah-Bortnyak, R.; Kuten, A.; Haick, H. Diagnosing Lung Cancer in Exhaled Breath Using Au Nanoparticles. Nature Nanotechnology 4, 669-673 (2009).

Bashouti, M. Y.; Tung, R. T.; Haick, H. Tuning Electrical Properties of Si Nanowire Field Effect Transistors by Molecular Engineering. Small 5(23), 2761-2769 (2009).

Barash, O.; Peled, N.; Hirsch, F. R.; Haick, H. Sniffing the Unique ”Odor Print” of Non-Small-Cell Lung Cancer with Gold Nanoparticles. Small 5(22), 2618-2624 (2009).

Yaffe, O.; Scheres, L.; Puniredd, S. R.; Stein, N.; Biller, A.; Har-Lavan, R.; Shpaisman, H.; Zuilhof, H.; Haick, H.; Cahen, D.*; Vilan, A.* Molecular Electronics at Metal/Semiconductor Junctions. Si Inversion by Sub-Nanometer Molecular Films. Nano Lett. 9(6), 2390-2394 (2009).

Haick, H.; Hakim, M.; Patrascua, M.; Levenberg, C.; Shehada, N.; Nakhoul, F.; Abassi, Z. Sniffing Chronic Renal Failure in Rat Models via an Array of Random Network of Single-Walled Carbon Nanotubes. ACS NANO, 3(5), 1258-1266 (2009).

Peng, G.; Tisch, U.; Haick, H. Detection of Nonpolar Molecules by Means of Carrier Scattering in Random Networks of Carbon Nanotubes: Towards Diagnosis of Diseases via Breath Samples. Nano Lett. 9(4), 1362-1368 (2009).

Dovgolevsky, E.; Tisch, U.; Haick, H. Chemically Sensitive Resistors Based on Monolayer-Capped Cubic Nanoparticles: Towards Configurable Nanoporous Sensors. Small 5(10), 1158-1161 (2009).

Assad, O.; Puniredd, S. R.; Stelzner, T.; Christiansen, S.; Haick, H. Stable Scaffolds for Reacting Si Nanowires with Further Organic Functionalities while Preserving Si-C Passivation of Surface Sites. J. Am. Chem. Soc. 130(52), 17670-17671 (2008).

Peng, G.; Trock, E.; Haick, H. Detecting Simulated Patterns of Lung Cancer Biomarkers by Random Network of Single-Walled Carbon Nanotubes Coated with Nonpolymeric Organic Materials. Nano Lett. 8(11), 3631-3635 (2008).

Puniredd, S. R.; Assad, O.; Haick, H. Highly Stable Organic Monolayers for Reacting Si with Further Functionalities: The Effect of C-C Bond nearby the Si Surface. J. Am. Chem. Soc. 130(41), 13727-13734 (2008).

Dovgolevsky, E.; Haick, H. Direct Observation of the Transition Point between Quasi-Spherical and Cubic Nanoparticles in Two-Step Seed-Mediated Growth Method. Small 4(11), 2059-2066 (2008).

Puniredd, S. R.; Assad, O.; Haick, H. Highly Stable Organic Modification of Si (111) Surfaces: Towards Reacting Si with Further Functionalities while Preserving the Desirable Chemical Properties of Full Si-C atop Site Terminations. J. Am. Chem. Soc. 130(29), 9184-9185 (2008).

Haick, H.*; Cahen, D. Making Contact: Connecting Molecules Electrically to the Macroscopic World. Prog. Surf. Sci. 83(4), 217-261 (2008).

Haick, H.; Cahen, D. Contacting Organic Molecules by Means of Soft Methods: Towards Molecule-Based Electronic Devices. Acc. Chem. Res. 41(3), 359-366 (2008).