A group of people sitting together

Avi Schroeder

Schroeder
Assistant Professor
Phone:
0778871953
avids@technion.ac.il
Room:
351
Links:

Personal Info

Ph.D. 2009, Ben-Gurion University

Research Fields

Our research group is aimed at improving patients’ quality of life and bettering their treatment by developing innovative medical technologies.
Specifically, we will focus on targeting metastatic cancer with nanotechnology, and on constructing miniature medical devices that couple diagnosis to therapy (theranostic devices).

Research Topics

At MIT, Avi and his colleagues developed nanoparticles that are capable of autonomously synthesizing proteins upon signal, thereby being injectable nano-factories for on-site production of drugs. In addition, he is an inventor of the uPill™ – a capsule that houses an entire ultrasound machine inside of it. The pill can be swallowed and excreted naturally and is used as a novel technology for enabling the oral administration of therapeutics that are currently administered by injection.
Avi’s PhD research involved the development of drug-loaded nanoparticles (nano liposomes) that can be triggered with ultrasound to release an anti-cancer chemotherapeutic in tumors, thereby improving the therapeutic efficacy and reducing side-effects. In addition, during these experiments it was discovered that nanoparticles used for drug delivery also have unique mechanical properties, and that carefully designed particles reduce cartilage’ friction and wear and enable its regeneration. These particles have already been translated to the clinic (Phase I/II by Moebius Medical LTD), where patients with osteoarthritis are receiving this novel treatment.
About – dr. Avi Schroeder received all three degrees in Chemical Engineering (BSc ‘03, MSc ‘05, PhD ‘09) from the Ben-Gurion University. His MSc and PhD research was performed with professors Joseph Kost (BGU) and Yechezkel Barenholz (Hebrew University – Hadassah Medical School). Avi’s postdoctoral training (2009-2012) was conducted with Institute professor Robert Langer and Daniel G. Anderson at the Massachusetts Institute of Technology. Throughout his studies Avi was awarded national and international awards including an Eshkol PhD Fellowship, the Intel Nanotechnology-, TEVA Pharmaceuticals-, and the Wolf Foundation PhD Awards, as well as the MIT–Koch Biomedical Imaging Award and others.

Publications

Remotely-activated protein-producing nanoparticles
Avi Schroeder, Michael S. Goldberg Christian Kastrup Christopher G. Levins, Robert Langer and Daniel G. Anderson, NanoLetters, 2012, in press.
Highlighted in: Nature, 2012, 484, 290.
Alkane-modified short polyethyleneimine for siRNA delivery
Avi Schroeder, James Dahlman, Gaurav Sahay, Kevin T. Love, Yingxia Wang and Daniel G. Anderson, Journal of Controlled Release, in press.
Treating metastatic cancer with nanotechnology
Avi Schroeder, Daniel A. Heller, Monte  M. Winslow, James E. Dahlman, George W. Pratt, Robert Langer, Tyler Jacks and Daniel G. Anderson, Nature Rev. Cancer, 2011, 12(1), 39-50.
Nanoparticles for targeting the infarcted heart
Tal Dvir, Michael Bauer, Avi Schroeder, Jonathan Tsui, Daniel G. Anderson, Robert Langer, Ronglih Liao, and Daniel S. Kohane, NanoLetters, 2011, 11(10), 4411–4414.
Liposomes for HIV prophylaxis
Nikita Malavia, David Zurakowski, Avi Schroeder, Anna Laury, Hila Epstein-Barash, Joseph Sodroski, Robert Langer, Navid Madani, and Daniel S. Kohane. Biomaterials, 2011, 32(33):8663-8.
Boundary lubricants with exceptionally-low friction coefficients based on 2-D close-packed phosphatidylcholine liposomes
Ronit Golberg, Avi Schroeder, Keren Torgeman, Yechezkel Barenholz, Jacob Klein. Advanced Materials, 2011, 23(31):3517-21.
Interactions between adsorbed unilamellar HSPC vesicles on mica surfaces across conditions of physiological osmolarity
Ronit Goldberg, Avi Schroeder, Yechezkel Barenholz, Jacob Klein. Biophysical Journal, 2011, 100(10) 2403-2411.
Polyhydroxylated Fatty Alcohols Derived from Avocado Suppress Inflammatory Response and Provide Non-Sunscreen Protection Against UV-induced Damage In Skin Cells
Gennady Rosenblat, Shai Meretski, Joseph Segal, Mark Tarshih, Avi Schroeder, Alexandra Zanin, Malka Hochberg. Archives of Dermatological Research, 2011, 303(4) 239-46.
Using Liposomes to Target Infection and Inflammation Induced by a Foreign Body Injury
Avi Schroeder, Keren Turjeman, Josh E. Schroeder, Meir Leibergall, Yechezkel Barenholz. Expert Opinion on Drug Delivery, 2010, 7(10) 1175-1189.
Liposomes as Potential Biolubricant Additives for Wear Reduction in Human Synovial Joints
Gabi Verberne, Avi Schroeder, Grigory Halprin, Yechezkel Barenholz, Izhak Etsion. Wear, 2010, 268 (7-8) 1037-1042.
Liposomes Act as Effective Biolubricants for Friction Reduction in Human Synovial Joints
Sarit Sivan* and Avi Schroeder* (*Equal contribution), Gabi Verberne, Yulia Merkher, Dvora Diminsky, Aba Priev, Alice Maroudas, Gregory Halperin, Dorrit Nitzan, Izhak Etsion, Yechezkel Barenholz. Langmuir, 2010, 26 (2), 1107–1116.
Lipid-Based Nanotherapeutics for siRNA Delivery
Avi Schroeder, Christopher G. Levins, Christina Cortez, Robert Langer, Daniel G. Anderson, J. Internal Medicine, 2010, 267(1), 9-21.
A Mathematical Model of Drug Release from Liposomes by Low Frequency Ultrasound
Giora Enden, Avi Schroeder.   Annals Biomedical Eng., 2009, 37 (12), 2640-2645.
Ultrasound, Liposomes, and Drug Delivery: Principles for Using Ultrasound to Control the Release of Drugs from Liposomes
Avi Schroeder, Joseph Kost, Yechezkel Barenholz, Chem. Phys. Lipids, 2009, 162 (1-2), 1-16.
Ultrasound Triggered Release of Cisplatin from Liposomes in Murine Tumors
Avi Schroeder, Reuma Honen, Keren Turjeman, Alberto Gabizon, Joseph Kost and Yechezkel Barenholz. J. Controlled Release, 2009, 137 (1), 63-68.
Using PEGylated Nano-Liposomes to Target Tissue Invaded by a Foreign Body
Avi Schroeder, Alex Sigal, Keren Turjeman and Yechezkel Barenholz, J. Drug Targeting, 2008, 16 (7-8), 591-595.
Surface Active Phospholipids as Cartilage Lubricants
Avi Schroeder, Gabi Verberne, Yulia Merkher, Dvora Diminsky, Alice Maroudas, Gregory Halperin, Alexandra Barbur, Dorrit Nitzan, Izhak Etsion, Yechezkel Barenholz, Sarit Sivan, Proc. ASME ESDA, 2008, 3, 549-553.
Triggered Release of Aqueous Content from Liposome-Derived Sol-Gel Nano-Capsules
Yael Steinberg, Avi Schroeder, Yeshayahu Talmon, Judith Schmidt, Rafail L. Khalfin, Yachin Cohen, Jean-Marie Devoisselle, Sylvie Begu, and David Avnir, Langmuir, 2007, 23 (24), 12024-12031.
Controlling Liposomal Drug Release by Low-Frequency Ultrasound: Mechanism and Feasibility
Avi Schroeder, Yuval Avnir, Sara Weisman, Yousef Najajreh, Alberto Gabizon, Yeshayahu Talmon, Joseph Kost, and Yechezkel Barenholz, Langmuir, 2007, 23 (7), 4019-4025.